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The Nigrostriatal Dopaminergic System Assessed in Vivo by PET Volunteers & Pts with Parkinson's Disease Arch Neurol 47:1290-1298, Leenders,K.L.,et al, 1990 See this aricle in Pubmed Article Abstract Both 6-L(18F)-fluorodopa and(11C)-nomifensine tracer uptake in putamen was decreased on average to 40%of normal values,suggesting that a substantial part of the cellular elements of the dopaminergic nigrostriatal system is still intact in living parkinsonian patients.This is in contrast to the generally extreme depletion of endogenous dopamine in the putamen of patients found at postmortem.Our results lend support to the search for drug treatments that protect against further nigrostriatal cell loss and that could be exhibited as soon as the disease manifests clinically.If successful,a sufficient striatal nerve terminal pool would remain so that the effectiveness of levodopa as a dopamine repletor could persist.

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